Maternal immunization

Abstract

Maternal immunization holds tremendous promise to improve maternal and neonatal health for a number of infectious conditions. The unique susceptibilities of pregnant women to infectious conditions, as well as the ability of maternally-derived antibody to offer vital neonatal protection (via placental transfer), together have produced the recent increased attention on maternal immunization. The Advisory Committee on Immunization Practices (ACIP) currently recommends 2 immunizations for all pregnant women lacking contraindication, inactivated Influenza and tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap). Given ongoing research the number of vaccines recommended during pregnancy is likely to increase. Thus, achieving high vaccination coverage of pregnant women for all recommended immunizations is a key public health enterprise. This review will focus on the present state of vaccine acceptance in pregnancy, with attention to currently identified barriers and determinants of vaccine acceptance. Additionally, opportunities for improvement will be considered.

Keywords:

• pregnancy
• influenza
• pertussis
• vaccine
• vaccination
• immunization

Abbreviations:

• Tdap, tetanus toxoid, reduced diphtheria toxoid and acellular pertussis
• ACIP, Advisory Committee on Immunization Practices
• ACOG, American College of Obstetricians and Gynecologists
• AAP, American Academy of Pediatrics
• MMR, measles, mumps, and rubella
• CDC, Centers for Disease Control and Prevention

Disclosure of Potential Conflicts of Interest

No potential conflicts of interest were disclosed.