Advanced search
Publication Cover
Autophagy Volume 9, 2013 - Issue 10
Submit an article Journal homepage
4,601
Views
127
CrossRef citations to date
0
Altmetric
Review

Cardiovascular autophagy

Concepts, controversies, and perspectives

Sergio Lavandero Center for Molecular Studies of the Cell; Faculty of Chemical & Pharmaceutical Sciences/ Faculty of Medicine; University of Chile; Santiago, Chile; Department of Internal Medicine (Cardiology Division); University of Texas Southwestern Medical Center; Dallas, TX USA
,
Rodrigo Troncoso Center for Molecular Studies of the Cell; Faculty of Chemical & Pharmaceutical Sciences/ Faculty of Medicine; University of Chile; Santiago, Chile
,
Beverly A Rothermel Department of Internal Medicine (Cardiology Division); University of Texas Southwestern Medical Center; Dallas, TX USA; Department of Molecular Biology; University of Texas Southwestern Medical Center; Dallas, TX USA
,
Wim Martinet Laboratory of Physiopharmacology; University of Antwerp; Antwerp, Belgium
,
Junichi Sadoshima Department of Cell Biology and Molecular Medicine; Rutgers New Jersey Medical School; Newark, NJ USA
&
Joseph A Hill Department of Internal Medicine (Cardiology Division); University of Texas Southwestern Medical Center; Dallas, TX USA; Department of Molecular Biology; University of Texas Southwestern Medical Center; Dallas, TX USACorrespondence[email protected]
Pages 1455-1466 | Received 13 Apr 2013, Accepted 30 Jul 2013, Published online: 14 Aug 2013
 
Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days

Abstract

Despite recent scientific and technological advances, cardiovascular disease remains the leading cause of morbidity and mortality worldwide. Autophagy, an evolutionarily ancient response to cellular stress, has been implicated in the pathogenesis of a wide range of heart pathologies. However, the precise role of autophagy in these contexts remains obscure owing to its multifarious actions. Here, we review recently derived insights regarding the role of autophagy in multiple manifestations of cardiac plasticity and disease.

10.4161/auto.25969

Disclosure of Potential Conflicts of Interest

No potential conflicts of interest were disclosed.

Acknowledgments

This work was supported by Grants from CONICYT, Chile (FONDECYT 1120212 and FONDECYT 3110114 to SL and RT, respectively; Anillo ACT grant 1111 to SL, Red 120003 to SL and JAH), the NIH (HL-080144, JAH; HL-0980842, JAH; HL-100401, JAH; HL-072016, BAR; HL-097768, BAR), CPRIT (RP110486P3, JAH), the AHA DeHaan Foundation (0970518N, JAH), and the Fondation Leducq (11CVD04, JAH).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related Research Data

Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis
Source: Cold Spring Harbor Laboratory
Role of autophagy in atherosclerosis: foe or friend?
Source: Springer Science and Business Media LLC
Everolimus Inhibits Monocyte/Macrophage Migration in Vitro and Their Accumulation in Carotid Lesions of Cholesterol-Fed Rabbits
Source: American Society for Pharmacology & Experimental Therapeutics (ASPET)
Molecular Mechanisms in Heart Failure: Focus on Cardiac Hypertrophy, Inflammation, Angiogenesis, and Apoptosis
Source: Elsevier BV
Increased myocardial cathepsin D activity during regression of thyrotoxic cardiac hypertrophy
Source: Springer Science and Business Media LLC
The protective role of autophagy in nephrotoxicity induced by bismuth nanoparticles through AMPK/mTOR pathway.
Source: Taylor & Francis
Transplanted Mesenchymal Stem Cells Reduce Autophagic Flux in Infarcted Hearts via the Exosomal Transfer of miR-125b.
Source: Ovid Technologies (Wolters Kluwer Health)
Titrating autophagy in cardiac plasticity.
Source: Informa UK Limited
Subcellular remodeling as a viable target for the treatment of congestive heart failure.
Source: SAGE Publications
Iron induces insulin resistance in cardiomyocytes via regulation of oxidative stress
Source: Springer Science and Business Media LLC
Cardioprotective mechanisms of salvianic acid A sodium in rats with myocardial infarction based on proteome and transcriptome analysis
Source: Springer Science and Business Media LLC
p62 at the Crossroads of Autophagy, Apoptosis, and Cancer
Source: Elsevier BV
Therapeutic Use of MicroRNAs in Myocardial Diseases
Source: Springer Science and Business Media LLC
Autophagy is an adaptive response in desmin-related cardiomyopathy
Source: Proceedings of the National Academy of Sciences
A Report From the American Heart Association
Source: Ovid Technologies (Wolters Kluwer Health)
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway
Source: Springer Science and Business Media LLC
Lactone Component From Ligusticum chuanxiong Alleviates Myocardial Ischemia Injury Through Inhibiting Autophagy.
Source: Frontiers Media SA
Regulation Mechanisms and Signaling Pathways of Autophagy
Source: Annual Reviews
Protein kinase A is a target for aging and the aging heart.
Source: Impact Journals, LLC
A Report From the American Heart Association
Source: Ovid Technologies (Wolters Kluwer Health)
DAP1, a Novel Substrate of mTOR, Negatively Regulates Autophagy
Source: Elsevier Ltd.
Distinct Classes of Phosphatidylinositol 3′-Kinases Are Involved in Signaling Pathways That Control Macroautophagy in HT-29 Cells
Source: Elsevier BV
MyD88 and Trif Target Beclin 1 to Trigger Autophagy in Macrophages
Source: American Society for Biochemistry & Molecular Biology (ASBMB)
MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice
Source: American Society for Clinical Investigation
Autophagy in alcohol-induced multiorgan injury: mechanisms and potential therapeutic targets.
Source: Hindawi Limited
Tor-Mediated Induction of Autophagy via an Apg1 Protein Kinase Complex
Source: Rockefeller University Press
Selective clearance of macrophages in atherosclerotic plaques by autophagy.
Source: Elsevier BV
The role of autophagy emerging in postinfarction cardiac remodelling
Source: Oxford University Press (OUP)
Regulation of autophagy by cytoplasmic p53
Source: Springer Science and Business Media LLC
Autophagy is impaired in cardiac ischemia-reperfusion injury
Source: Informa UK Limited
No upregulation of lectin-like oxidized low-density lipoprotein receptor-1 in serum-deprived EA.hy926 endothelial cells under oxLDL exposure, but increase in autophagy.
Source: Elsevier BV
mTOR signaling in growth control and disease.
Source: Elsevier BV
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy.
Source: Elsevier BV
Deacetylation of FoxO by Sirt1 plays an essential role in mediating starvation-induced autophagy in cardiac myocytes
Source: Ovid Technologies (Wolters Kluwer Health)
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
Source: Springer Science and Business Media LLC
Remodeling and reparation of the cardiovascular system.
Source: Elsevier BV
Panax notoginseng saponins attenuate cardiomyocyte apoptosis through mitochondrial pathway in natural aging rats.
Source: Wiley
Mechanical Unloading Activates FoxO3 to Trigger Bnip3-Dependent Cardiomyocyte Atrophy
Source: Ovid Technologies (Wolters Kluwer Health)
Resveratrol Attenuates Doxorubicin-Induced Cardiomyocyte Death via Inhibition of p70 S6 Kinase 1-Mediated Autophagy
Source: American Society for Pharmacology & Experimental Therapeutics (ASPET)
mTOR complex 2 signaling and functions
Source: Informa UK Limited
Modest overexpression of FOXO maintains cardiac proteostasis and ameliorates age‐associated functional decline
Source: Wiley
Exchange protein directly activated by cAMP 1 promotes autophagy during cardiomyocyte hypertrophy
Source: Oxford University Press (OUP)
The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress.
Source: Springer Science and Business Media LLC
Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice
Source: Springer Science and Business Media LLC
Rationale for Stents Eluting Everolimus and a Glucocorticoid
Source: (:unav)
Roles of Apoptosis, Inflammation, and Fibrosis
Source: Ovid Technologies (Wolters Kluwer Health)
AUTOPHAGY IN CHRONICALLY ISCHEMIC MYOCARDIUM
Source: Proceedings of the National Academy of Sciences
AMPK in Health and Disease
Source: American Physiological Society
Self-eating and self-killing: crosstalk between autophagy and apoptosis
Source: Springer Science and Business Media LLC
Suppression of Class I and II Histone Deacetylases Blunts Pressure-Overload Cardiac Hypertrophy
Source: Ovid Technologies (Wolters Kluwer Health)
Phenotypic plasticity of adult myocardium: molecular mechanisms
Source: The Company of Biologists
Intracellular protein aggregation is a proximal trigger of cardiomyocyte autophagy.
Source: Ovid Technologies (Wolters Kluwer Health)
Urocortin inhibits Beclin1-mediated autophagic cell death in cardiac myocytes exposed to ischaemia/reperfusion injury
Source: Elsevier BV
Autophagy plays a protective role in free cholesterol overload-induced death of smooth muscle cells
Source: American Society for Biochemistry & Molecular Biology (ASBMB)
Regulation of Mammalian Autophagy in Physiology and Pathophysiology
Source: American Physiological Society
The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling.
Source: Elsevier BV
Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue
Source: Portland Press Ltd.
Clinical outcome and phenotypic expression in LAMP2 cardiomyopathy.
Source: American Medical Association (AMA)
Effects of wortmannin on cardioprotection exerted by ischemic preconditioning in rat hearts subjected to ischemia-reperfusion.
Source: Springer Science and Business Media LLC
Exogenous NAD Blocks Cardiac Hypertrophic Response via Activation of the SIRT3-LKB1-AMP-activated Kinase Pathway
Source: American Society for Biochemistry & Molecular Biology (ASBMB)
Unsaturated lipid peroxidation-derived aldehydes activate autophagy in vascular smooth-muscle cells
Source: Portland Press Ltd.
Toll-like receptors control autophagy
Source: Wiley
Mechanisms: Part 1 of 2
Source: Ovid Technologies (Wolters Kluwer Health)
Mitochondria regulate autophagy
Source: Wiley
Insulin-Like Growth Factor 1 in the Cardiovascular System
Source: Springer International Publishing
Macroautophagy and Chaperone-Mediated Autophagy in Heart Failure: The Known and the Unknown
Source: Hindawi Limited
A Potential Drug Target for Plaque Stabilization
Source: Ovid Technologies (Wolters Kluwer Health)
LKB1 and AMP‐activated protein kinase control of mTOR signalling and growth
Source: Wiley
TSC2 mediates cellular energy response to control cell growth and survival.
Source: Elsevier BV
HDLs inhibit endoplasmic reticulum stress and autophagic response induced by oxidized LDLs.
Source: Springer Science and Business Media LLC
A Potential Drug Target for Plaque Stabilization
Source: Ovid Technologies (Wolters Kluwer Health)
Adriamycin-induced autophagic cardiomyocyte death plays a pathogenic role in a rat model of heart failure
Source: Elsevier BV
A Potential Drug Target for Plaque Stabilization
Source: Ovid Technologies (Wolters Kluwer Health)
Autophagy in Hypertensive Heart Disease
Source: American Society for Biochemistry & Molecular Biology (ASBMB)
A Potential Drug Target for Plaque Stabilization
Source: Ovid Technologies (Wolters Kluwer Health)
Inflammatory cytokines associated with cancer growth induce mitochondria and cytoskeleton alterations in cardiomyocytes.
Source: Wiley
Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria
Source: HAL CCSD
The altered expression of autophagy-related genes participates in heart failure: NRBP2 and CALCOCO2 are associated with left ventricular dysfunction parameters in human dilated cardiomyopathy.
Source: Public Library of Science (PLoS)
Autophagy signaling through reactive oxygen species.
Source: Mary Ann Liebert Inc
Activation of CD137 Signaling Enhances Vascular Calcification through c-Jun N-Terminal Kinase-Dependent Disruption of Autophagic Flux
Source: Hindawi Limited
Cardiac autophagy is a maladaptive response to hemodynamic stress
Source: American Society for Clinical Investigation

Linking provided by 
Download PDF

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.