Impaired mitophagy at the heart of injury

Abstract

Recent publications link mitophagy mediated by PINK1 and Parkin with cardioprotection and attenuation of inflammation and cell death. The field is in need of methods to monitor mitochondrial turnover in vivo to support the development of new therapies targeting mitochondrial turnover.

Keywords: :

• mitophagy
• mitochondria
• cardiac
• ischemia
• inflammation
• Parkin
• cytokine