A bilateral primary yolk sac tumor of the lung associated with chromosome 3 polysomy

Understanding the Oct 3/4 and Sox 2 interaction

Shitij Arora Department of Medicine; Wyckoff Heights Medical Center; New York-Presbyterian Health Care System; Affiliate Weil Medical College of Cornell University; New York, NY USACorrespondence[email protected]

Harish Patel Department of Medicine; Wyckoff Heights Medical Center; New York-Presbyterian Health Care System; Affiliate Weil Medical College of Cornell University; New York, NY USA

Pervez Mir Department of Medicine; Wyckoff Heights Medical Center; New York-Presbyterian Health Care System; Affiliate Weil Medical College of Cornell University; New York, NY USA

Sneha Mishra Department of Medicine; Wyckoff Heights Medical Center; New York-Presbyterian Health Care System; Affiliate Weil Medical College of Cornell University; New York, NY USA

Amita Kalra Department of Medicine; Wyckoff Heights Medical Center; New York-Presbyterian Health Care System; Affiliate Weil Medical College of Cornell University; New York, NY USA

Harinder Sawhney Department of Medicine; Wyckoff Heights Medical Center; New York-Presbyterian Health Care System; Affiliate Weil Medical College of Cornell University; New York, NY USA

Frantz Duffoo Department of Medicine; Wyckoff Heights Medical Center; New York-Presbyterian Health Care System; Affiliate Weil Medical College of Cornell University; New York, NY USA

Mike Macera Department of Genetics; Wyckoff Heights Medical Center; New York-Presbyterian Health Care System; Affiliate Weil Medical College of Cornell University; New York, NY USA

Afaf Abdu Department of Pathology; Wyckoff Heights Medical Center; New York-Presbyterian Health Care System; Affiliate Weil Medical College of Cornell University; New York, NY USA

William Thelmo Department of Pathology; Wyckoff Heights Medical Center; New York-Presbyterian Health Care System; Affiliate Weil Medical College of Cornell University; New York, NY USA

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Abstract

Extragonadal germ cell tumors (EGCTs) in the lung are extremely rare and their pathogenesis is poorly understood. We report a case in a 48-year-old female which was very aggressive and stained positive for primoridial germ cell markers. Interestingly, there was chromosome 3 polysomy noted. To our knowledge this is the first chromosomal aberration noted in a primary germ cell tumor of the lung.

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A bilateral primary yolk sac tumor of the lung associated with chromosome 3 polysomy

Understanding the Oct 3/4 and Sox 2 interaction

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A bilateral primary yolk sac tumor of the lung associated with chromosome 3 polysomy

Understanding the Oct 3/4 and Sox 2 interaction

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