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Abstract
NFκB represents a key transcription factor within the inflammatory tumor microenvironment; however, NFκB’s function in tumor-initiating cells has not been examined yet. A recent Cell paper by Schwitalla et al. reports that NFκB modulates Wnt signaling and shows that enhanced Wnt activation induces dedifferentiation of nonstem cells that acquire tumor-initiating capacity.
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Disclosure of Potential Conflicts of Interest
No potential conflicts of interest were disclosed.