Not so WEE

Abstract

It has been known for many years that manipulation of cell cycle checkpoint function represents one approach by which the toxicity of chemotherapy and of ionizing radiation can be increased in tumor cells.^1-3 In particular, abrogation of the G₂/M checkpoint has been shown to enhance the lethality of a wide range of toxic stresses.^1-3 Inhibition of the G₂/M checkpoint after chemotherapy/irradiation would result in tumor cells entering mitosis with damaged DNA, which would in turn result in loss of clonogenic survival (i.e., a lethal mitosis).

Keywords: :

• CDK1
• G2/M checkpoint
• MK-1775
• WEE1
• apoptosis
• cisplatin
• mesothelioma

This article refers to:

Abrogating G2/M checkpoint through WEE1 inhibition in combination with chemotherapy as a promising therapeutic approach for mesothelioma

10.4161/cbt.27623

Disclosure of Potential Conflicts of Interest

No potential conflicts of interest were disclosed.

Acknowledgments

P Dent is funded by R01 DK52825.