Receptor tyrosine kinase mutations: Molecular indicators for therapeutic response or signposts marking important signaling pathways?

Abstract

Commentary to:

Activating Mutations in c-KIT and PDGFR? Are Exclusively Found in Gastrointestinal Stromal Tumors and Not in Other Tumors Overexpressing these Imatinib Mesylate Target Genes

Herman Burger, Michael A. den Bakker, Johan M. Kros, Hans van Tol, Alex M. de Bruin, Wolter Oosterhuis, Harry F.G.M. van den Ingh, Erwin van der Harst, Hans. P. de Schipper, Erik A.C. Wiemer and Kees Nooter