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Abstract
Objective To investigate the role of antiapoptosis gene, survivin involved in regulating cell sensitivity to taxanes and platinum compounds. Methods Cultured human epithelial ovarian cancer cell line A2780 and its platinum (DDP)-resistance cell line A2780/DDP were divided into three groups as control, treatment with DDP, and treatment with Taxol Expression of mdr1 and survivin genes in each group was detected by using Reverse transcription-polymerase chain reaction (RT-PCR). Apoptosis in the ovarian cancer cell lines was measured by flow cytometry. Results After treatment with DDP for 48 h, relative survivin expression was significantly lower than that of no drug given (p