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Abstract
Use of multi-modality small animal imaging to experimentally demonstrate the effectiveness of FDG-PET/CT as an oncologic imaging modality independent of tumor p53 status. Wang et al., in this issue of Cancer Biology and Therapy, demonstrated that HCT116-p53+/+ tumors (green) and HCT116-p53-/- tumors (red) grown on opposite flanks of the same mouse (top figures) both efficiently trap the glucose analogue F18-FDG (bottom figures) despite the proposed role of p53 in controlling the Warburg effect. In the report, the authors additionally created an inducible HCT116 colorectal cancer cell line that can be induced to Knockdown p53 and functionally imaged via p53-inducible firefly luciferase expression. This model system was used to examine the short term consequences of p53 knockdown on F18-FDG uptake. This novel approach using the power of multi-modality small animal imaging will be valuable to assess the effects of p53 and other oncogenes on the effectiveness of new oncologic tracer candidates that are currently being tested for clinical use.