Downregulation of IgG Fc binding protein (FcγBP) in prostate cancer

Abstract

By means of protein expression profile, mass spectral and/or RT-PCR analyses we found for the first time IgG Fc binding protein (FcγBP), distinct from Fcγ receptors is expressed in both human and mouse prostates. There is a strong correlation between downregulation of FcγBP and the progression of prostate cancer in Transgenic Adenocarcinoma Mouse Prostate (TRAMP) mice. FcγBP gene expression is significantly reduced or lost in human prostate tumor tissues and prostate cell lines. The differentially expressed FcγBP could reflect its potential role in prostate malignancy as well as an indicator for progression of the cancer.