Cover Caption

Abstract

The antioxidant properties of fruits and vegetables have been highly touted as a means to prevent diseases such as cancer, heart disease and diabetes. Flavenoids are natural polyphenolic compounds in fruits and vegetables with anti-oxidant properties. The signaling pathways activated by flavenoids are becoming better unraveled. The cover of the current issue of Cancer Biology and Therapy shows a confocal, immunofluorescent image of Mcf-7 breast cancer cells, cultured in 3D and treated with kaempferol, a flavenoid shown to induce apoptosis in these cells. The green staining shows the redistribution of ERK in the cells after treatment with kaempferol, while DAPI staining (blue) identifies cell nuclei. To learn more about the effect of kaempferol on the viability of Mcf-7 cells, see the paper by Kim et al.