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Abstract
The purpose of this study was to prospectively evaluate the use of ultrasonographically guided
high-intensity focused ultrasound (HIFU) in the salvage of limbs in patients with osteosarcoma.
Seven patients underwent HIFU ablation. Laboratory and radiologic examinations were performed
after intervention. Changes in symptoms and survival time were noted at follow-up. No severe
complications were observed, and preexisting severe pain disappeared in patients treated with
HIFU. Alkaline phosphatase did not show statistically significant changes before and after HIFU
treatment, although Alkaline phosphatase did change 1 mo and 2 mo after HIFU. Complete
response [amp1]of the tumor was achieved in 3 patients with osteosarcoma. Partial response was
achieved in another 3 patients treated with HIFU. Pulmonary metastasis was noted in only one
patient 5 mo after HIFU. The median survival time was 68 months. All patients were alive 3 yrs
after HIFU treatment. Five patients were alive at follow-up visits after 5 yrs. One patient died
from cachexia and infection after 4 yrs, another patient died of cardiac arrestttack after 4 yrs.
Three patients died of lung dysfunction from pulmonary metastases after 5 yrs. The five-year
survival rate was 71.4%. The authors concluded that HIFU ablation was a safe and feasible
method of treatment of osteosarcome which salvages the limb, but large-scale randomized clinical
trials are necessary for confirmation.
