Cover caption

Abstract

First described as a B-cell transcription factor, NFkB has been shown to be important for cell survival in many types of cancer where its nuclear translocation promotes activation of pro-survival genes. The best-studied NFkB signaling pathway is the “classical” pathway, but NFkB is also able to signal through a “non-canonical” pathway. The role of this pathway in cancer cell survival is less clear. In the current issue of Cancer Biology & Therapy, Wharry and colleagues examine the role of the non-canonical pathway in Pancreatic cancer. The cover image, taken from their manuscript, shows a section of a pancreatic adenocarcinoma stained for p100/p53 (green) and RelB (red). DAPI is used to stain the nuclei (blue). In this merged image, yellow indicates the colocalization of p100/p52 and RelB while white areas indicate NFkB that is localized to the nucleus. More information about the noncanonical NFkB pathway in pancreatic adenocarcinoma can be found in the paper by Wharry and colleagues.