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Abstract
Testing agents already approved for other indications is becoming a popular approach to cancer drug development. In this month’s issue of Cancer Biology & Therapy, Marino and colleagues begin to dissect a clinical observation made by several groups: GCSF used to treat chemotherapy-associated neutropenia sometimes decreases the size of the tumor. Marino and colleagues demonstrate that if they treat mammary tumors with GCSF, there is a decrease in tumor weight and size but no effects are seen when GCSF is used on the tumor cells in vitro. This month’s cover of Cancer Biology & Therapy shows a section from a PBS-treated tumor stained with H&E. To see the effects of the GCSF on the mammary tumors and to learn more about the signaling pathways involved, see the article by Marino and colleagues.