Elevated expression of nuclear Hsp90 in invasive breast tumors

Abstract

With the current trend for early breast cancer detection, there is also a growing demand for discovering markers to assist in the patient risk stratification. Molecular chaperones play essential roles in the post-translational maturation of oncogenic client proteins and are strongly associated with carcinogenesis. To better define the role of chaperones in breast cancer, tissue arrays were immunostained for the chaperones Hsp90 and p23 and assessed in terms of reactivity, intensity, and cellular localization. Cytoplasmic Hsp90 protein expression was significantly stronger in ductal carcinoma in situ and invasive breast carcinomas as compared to normal breast tissue (p