Cover Caption

Abstract

Overcoming resistance to chemotherapy remains one of the biggest challenges in cancer therapy. Cells develop a myriad of mechanisms to allow survival in the face of therapeutic agents. In the current issue of Cancer Biology & Therapy, Pataer and colleagues explore the role of PRK, a kinase with an anti-viral role, in the response to chemontherapy. Using an adenovirus expressing a dominant negative form of PKR, the authors show that inhibiting PKR induces ER stress resulting in caspase-4 mediated cell death. On the cover, they show that dominant negative PKR (green) localizes to the ER (shown in red using an ER tracker dye, colocalization shown in orange). Nucleic acid staining is shown in blue (DAPI). To learn more about the role of PKR in cancer cells, see the article by Pataer and colleagues.