A phase I study of KH901, a conditionally replicating granulocyte-macrophage colony-stimulating factor: Armed oncolytic adenovirus for the treatment of head and neck cancers

Abstract

Ad5, adenovirus type 5; CNE, human nasopharyngeal carcinoma cell line; DLT, dose-

limiting toxicity; GM-CSF, granulocyte-macrophage colony-stimulating factor; HNC,

head and neck cancer; HRP,horseradish peroxidase; hTERT, human telomerase

reverse transcriptase; IL, interleukin; mtelo, modified promoter; MTD, maximum-

tolerated dose; NCI-CTC, National Cancer Institute Common Toxicity Criteria; PCR,

polymerase chain reaction; SDS-PAGE,sodium dodecyl sulphate polyacrylamide gel

electrophoresis; SCHNC, squamous cell head and neck cancer; TNF, tumor necrosis

factor; vp, virus particle