Abstract
Comment on: Xu R, et al. Cell Cycle 2010; 9:4315-4322.
Acknowledgements
D.C.R. is supported by National Institutes of Health Grant CA122086 and by support from the Mayo Clinic Breast Cancer Specialized Program of Research Excellence (SPORE) Grant CA116201 (to James Ingle).
Figures and Tables
Figure 1 Virgin daughters are more sensitive to acetic acid or heat stress than young mothers in (A) wild type and (B) Δsir2 strain. Crosses represent stress-induced death, where the size of the cross correlates with the death rate. Each scar depicts a division event. The red circles represent the total amount of damage, which is in wild type retained by the mother cell and in the Δsir2 strain distributed between the mother and the daughter. Thus, virgin Δsir2 daughters are more sensitive to stress than virgin wild-type daughters. Old Δsir2 mothers, on the other hand, are less sensitive to stress than old wild-type mothers, because Δsir2 mothers accumulate less damage.
![Figure 1 Virgin daughters are more sensitive to acetic acid or heat stress than young mothers in (A) wild type and (B) Δsir2 strain. Crosses represent stress-induced death, where the size of the cross correlates with the death rate. Each scar depicts a division event. The red circles represent the total amount of damage, which is in wild type retained by the mother cell and in the Δsir2 strain distributed between the mother and the daughter. Thus, virgin Δsir2 daughters are more sensitive to stress than virgin wild-type daughters. Old Δsir2 mothers, on the other hand, are less sensitive to stress than old wild-type mothers, because Δsir2 mothers accumulate less damage.](/cms/asset/1b4e6b98-6570-47a7-b3f4-3f7eacdae8c0/kccy_a_10914218_f0001.gif)