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Abstract
Comment on: Lee MH, et al. Mol Cell 2011; 43:180-91.
Figures and Tables
Figure 1 Feedback regulation of NFκB signaling induced by genotoxic agents. (A) NFκB activation by genotoxic stress involves SUMoylation of NEMO via PIASy (E3) and Ubc9 (E2), which leads to IKK activation. NFκB then activates the synthesis of SENP1 and SENP2 genes. SENP2 serves as the primary SUMO protease for NEMO, which leads to feedback attenuation of IKK and NFκB activation. (B) NFκB-dependent induction of SENP1 and SENP2 modulates SUMOylation status of other substrates.
Comment on: Lee MH, et al. Mol Cell 2011; 43:180 - 191; PMID: 21777808; http://dx.doi.org/10.1016/j.molcel.2011.06.017