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Abstract
Comment on: Lyons TR, et al. Nat Med 2011; 17:1109–15
Figures and Tables
Figure 1 Model of pro-tumorigenic immune modulation by phagocytic mammary epithelial cells. Upon the switch from lactation (left) to involution (right), milk-producing mammary epithelial cells undergo apoptosis (dark blue cells) and are extruded into the alveolar lumen. Other milk-producing mammary epithelial cells transition to become phagocytic (light blue cells) and engulf the shed apoptotic cells. Clearance of apoptotic cells is predicted to result in release of Th2-like cytokines and growth factors from the phagocytic mammary epithelial cells. This cytokine milieu is anticipated to promote alternative activation of macrophages (Mφ) and inhibition of cytotoxic T cells (CTL), resulting in an immunosuppressed, tumor-supportive microenvironment (green cells).
Comment on: Lyons TR, et al. Nat Med 2011; 17:1109 - 1115