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Cell Cycle Volume 11, 2012 - Issue 18
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The BTB-ZF transcription factors

Owen Siggs Department of Genetics; The Scripps Research Institute; La Jolla, CA USA; Henry Wellcome Building for Molecular Physiology; University of Oxford; Oxford, UKCorrespondence[email protected]
&
Bruce Beutler Center for Genetics of Host Defense; UT Southwestern Medical Center; Dallas, TX USA
Pages 3358-3369 | Received 11 Jun 2012, Accepted 26 Jun 2012, Published online: 16 Aug 2012
 
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Abstract

The BTB-ZF (broad-complex, tramtrack and bric-à-brac - zinc finger) proteins are encoded by at least 49 genes in mouse and man and commonly serve as sequence-specific silencers of gene expression. This review will focus on the known physiological functions of mammalian BTB-ZF proteins, which include essential roles in the development of the immune system. We discuss their function in terminally differentiated lymphocytes and the progenitors that give rise to them, their action in hematopoietic malignancy and roles beyond the immune system.

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