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Cell Cycle Volume 12, 2013 - Issue 18
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TGF-β: An emerging player in drug resistance

Diede Brunen Division of Molecular Carcinogenesis; The Netherlands Cancer Institute; Amsterdam, The Netherlands
,
Stefan Willems Division of Molecular Carcinogenesis; The Netherlands Cancer Institute; Amsterdam, The Netherlands; Department of Pathology; University Medical Centre Utrecht; Utrecht, The Netherlands
,
Udo Kellner Institut für Pathologie; Johannes Wesling Klinikum Minden; Minden, Germany
,
Rachel Midgley Department of Oncology; University of Oxford; Oxford, UK
,
Iris Simon Agendia; Amsterdam, The Netherlands
&
Rene Bernards Division of Molecular Carcinogenesis; The Netherlands Cancer Institute; Amsterdam, The NetherlandsCorrespondence[email protected]
Pages 2960-2968 | Received 01 Aug 2013, Accepted 02 Aug 2013, Published online: 12 Aug 2013
 
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Abstract

The transforming growth factor β (TGF-β) pathway acts as a double-edged sword in tumorigenesis. By constraining epithelial cell growth, TGF-β is a potent tumor suppressor. However, TGF-β also acts as a key player in the induction of epithelial-to-mesenchymal transition (EMT), thereby enhancing invasiveness and metastasis. Furthermore, TGF-β signaling has recently been correlated with resistance against both targeted and conventional anticancer agents. Here, we present data demonstrating a role for TGF-β in chemotherapy resistance in colorectal cancer (CRC). We discuss these results in the context of recent findings indicating TGF-β signaling as an emerging player in cancer drug resistance.

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