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Abstract
Signaling by the canonical Wnt pathway has multiple functions in stem cells. It caneither control stem cell expansion or –as we have recently demonstrated withneural crest stem cells– influence cell lineage decisions by promoting specific fatesat the expense of others. Thus, the role of canonical Wnt in stem cells is dependenton cell-intrinsic properties that determine how a cell responds to Wnt. Themolecular basis for the functional diversity of Wnt in different stem cell typesremains to be elucidated.