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Abstract
Epithelial-mesenchymal transition (EMT) is considered as an essential determinant ofcarcinoma progression. The transcription factor Snail controls EMT by repressing Ecadheringene expression and other epithelial genes. Snail protein stability and cellularlocalization is finely controlled by GSK3?-dependent phosphorylation and subsequentubiquitination. GSK3? phosphorylates Snail at two different motifs which induce itsnuclear export and association with ?-Trcp thus leading to Snail degradation. Recently,Snail was found to interact physical and functionally with LOXL2, a member of thelysyl oxidase gene family. Interestingly, LOXL2 seems to attenuate the GSK3?-dependent Snail degradation. Here, we discuss the relevance of this new potentialmechanism of regulation and the role of LOXL2 during carcinoma progression.