![Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5925/TOC-Subject-Sample-2021-Bioscience.jpg"})
Abstract
Unlike poly(ADP-ribose) polymerase-1 (PARP-1), poly(ADP-ribose) glycohydrolase(PARG) has long been a difficult protein to study. However, the complete absence ofPARG activity was recently characterized in mice via disruption of the murine PARG gene.As expected, PARG is critical for the maintenance of steady-state poly(ADP-ribose) levels.But surprisingly, the disruption of PARG led to embryonic lethality and increasedsusceptibility to mild cell stress. Therefore, the protective role of PARG and itsinvolvement in development indicate that these roads to viability go through PARG.