Tumor Profiling Turmoil

Abstract

Tumor profiling studies aim to determine gene expression signatures that can discriminate betweendifferent sub-types of tumors. We have recently discovered a signature that can reliably detectwhich primary head-neck tumors have metastasized to local lymph nodes. This signature has greatpotential for clinical application and also offers unique insights into how metastasis occurs. Despitethese obvious advances, discussed here alongside several other findings, such tumor profilingstudies are currently receiving harsh criticism. We make clear that such evaluations can themselvesalso be critically evaluated. The separation between the two factions actually shows that it is tooearly to either dismiss of exalt tumor profiling studies. Final judgment requires waiting for theresults of larger prospective studies carried out in parallel with current clinical practice.