Spermidinyl-CoA-based HAT inhibitors block DNA repair and provide cancer-specific chemo- and radiosensitization

Abstract

In the article by Bandyopadhyay et al. entitled “Spermidinyl-CoA-based HAT inhibitors block DNA repair and provide cancer-specific chemo- and radiosensitization,” which appeared in the September 1, 2009 issue of Cell Cycle (pp.2779-88), the first sentence in part (D) of the legend to Figure 3 appeared incorrectly as “(D) Inhibition of g-H2A.X acetylation by 1a: Top row – SDS-PAGE/Western of g-H2A.X in H358 cells treated with 10 µM CPT (1 hour) followed by incubation for an additional hour in the presence (right) or absence (left) of 50 µM 1a (60 µg/lane).” The correct sentence reads as follows: “(D) Inhibition of g-H2A.X acetylation by 1a: Top row – SDS-PAGE/Western of g-H2A.X in H358 cells treated with 5nM CPT (18 hours) in the presence (right lane) or absence (left lane) of 50 µM 1a (60 µg/lane).”

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Spermidinyl-CoA-based HAT inhibitors block DNA repair and provide cancer- specific chemo-and radiosensitization