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Abstract
Messenger RNA (mRNA) localization plays an important role in various cellular functions. To date, two general mechanisms have been identified for intracellular mRNA localization. The first one was identified by Blobel and colleagues more than three decades ago, by which mRNAs encoding for membrane and secreted proteins are targeted to the endoplasmic reticulum (ER) in a signal peptide dependent manner.1 The second mechanism is for the intracellular targeting of mRNAs encoding cytosolic proteins, which is dependent on specific sequence on the mRNA called zipcode.2 Recently, we have identified a new mechanism which targets Dia1 mRNA to the perinuclear ER in a zipcode-independent manner, even though the mRNA encodes a cytosolic protein.3 Here, we provide an updated discussion on how the Dia1 mRNA is targeted and what might be its physiological significance.
Acknowledgments
This work is supported by NIH grant R01GM070560. We thank Dr. Qingfen Li for proof reading.
Figures and Tables
Figure 1 Working model of Dia1 mRNA localization on the perinuclear ER.
Figure 2 Predicted potential translation pausing motif (CTR) in chicken and human Dia1 protein sequences. The CTR sequences are from reference Citation10. The CTR in both chicken and human Dia1 are overlapped with a portion of the GBD.
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