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Communicative & Integrative Biology Volume 4, 2011 - Issue 6
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The next phase of life-sciences spaceflight research: Harnessing the power of functional genomics

Timothy Etheridge Division of Clinical Physiology; University of Nottingham; Royal Derby Hospital; Derby, England
,
Kanako Nemoto Graduate School of Life Sciences; Tohoku University; Sendai, Japan
,
Toko Hashizume Advanced Engineering Services Co., Ltd.; Tsukuba, Japan
,
Chihiro Mori Graduate School of Life Sciences; Tohoku University; Sendai, Japan
,
Tomoko Sugimoto ISS Science Project Office; Institute of Space and Astronautical Science; Japan Aerospace Exploration Agency; Tsukuba, Japan
,
Hiromi Suzuki Japan Space Forum; Ohtemachi; Chiyoda-ku, Japan
,
Keiji Fukui Japan Space Forum; Ohtemachi; Chiyoda-ku, Japan
,
Takashi Yamazaki ISS Science Project Office; Institute of Space and Astronautical Science; Japan Aerospace Exploration Agency; Tsukuba, Japan
,
Akira Higashibata ISS Science Project Office; Institute of Space and Astronautical Science; Japan Aerospace Exploration Agency; Tsukuba, Japan
,
Nathaniel J Szewczyk Division of Clinical Physiology; University of Nottingham; Royal Derby Hospital; Derby, EnglandCorrespondence[email protected]
&
Atsushi Higashitani Graduate School of Life Sciences; Tohoku University; Sendai, Japan
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Pages 668-669 | Received 20 Jun 2011, Accepted 20 Jun 2011, Published online: 01 Nov 2011
 
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Abstract

Recently we demonstrated that the effectiveness of RNAi interference (RNAi) for inhibiting gene expression is maintained during spaceflight in the worm Caenorhabditis elegans and argued for the biomedical importance of this finding. We also successfully utilized green fluorescent protein (GFP)-tagged proteins to monitor changes in GPF localization during flight. Here we discuss potential applications of RNAi and GFP in spaceflight studies and the ramifications of these experiments for the future of space life-sciences research.

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