An integrated model for the nucleo-cytoplasmic transport of cytoplasmic poly(A)-binding proteins

Abstract

Cytoplasmic poly(A)-binding proteins (PABPs) regulate mRNA stability and translation. Although predominantly localized in the cytoplasm, PABP proteins also cycle through the nucleus. Recent work has established that their steady-state localization can be altered by cellular stresses such as ultraviolet (UV) radiation, and infection by several viruses, resulting in nuclear accumulation of PABPs. Here, we present further evidence that their interaction with and release from mRNA and translation complexes are important in determining their sub-cellular distribution and propose an integrated model for regulated nucleo-cytoplasmic transport of PABPs.

Keywords: :

• PABPC1
• PABPC4
• sub-cellular localization
• cellular stress response
• PABP
• translation initiation factor
• nucleo-cytoplasmic transport
• RNA-binding protein

Disclosure of Potential Conflicts of Interest

No potential conflicts of interest were disclosed.

Acknowledgments

H.M.B. and N.K.G. were supported by MRC Unit funding (HGU/HRSU), an MRC Senior Non-Clinical Fellowship G117/564 and MRC transition funding to N.K.G. N.K.G. is also supported by an MRC program grant and BBSRC and Wellcome Trust project grants.