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Abstract
Cdc42 is a key factor in the control of cell polarity and morphogenesis. Fission yeast Cdc42 regulates formin activation and actin cable assembly. Cdc42 is also required for exocyst function, contributing to polarized secretion. Additionally, Cdc42 participates in membrane trafficking, endosome recycling, and vacuole formation. We show here how Cdc42 is required for the correct transport/recycling to the plasma membrane of the glucan synthases Bgs1 and Bgs4, responsible of cell wall biosynthesis and polarized growth at the cell tips.
Acknowledgments
We thank Felice Kelly for advice and technical help. This work was supported by Grant BFU2010–15641 from the Comisión Interministerial de Ciencia y Tecnología, Spain. We acknowledge the institutional support granted to the IBFG by the Ramón Areces Foundation during 2011–2012. M. Estravís is receptor of a Titulado Superior contract founded by Junta de Castilla y León and Fondo Social Europeo.
