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Abstract
Synchronized spikes prevail in cortical networks, and their modulations are associated with attention, sensory processing, and motor behaviors, yet it remained unclear how spikes can synchronize at the millisecond precision in a noisy network. Our new evidence shows, however, that neurons do not easily synchronize; rather, in order to make them generate synchronous spikes, "parent" presynaptic neurons commonly shared by them are required to synchronize in advance. Therefore, the conventional style of neurophysiological research is unable to reach the true origin of synchronization.
Figures and Tables
Figure 1 Synchronization of presynaptic neuron layer is required to synchronous spikes of postsynaptic neuron pair. (A) Synaptic connection between two neurons by itself cannot synchronize them. (B) Common synaptic inputs from the presynaptic neuron layer contribute to postsynaptic spike synchronization to some extent but cannot fully account for the degree of naturally occurring synchronization. (C) Highly synchronized presynaptic neurons efficiently lead to postsynaptic synchronization.
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