Abstract
Usually, syringomas display a wide spectrum of benign adnexal neoplasms derived from the intraepidermal part of eccrine sweat ducts. Women are more frequently affected than men. Syringomas mainly occur in the periorbital area, but also affect the scalp, forehead, neck, abdomen, and extremities. A variety of clinical presentations of syringomas have been published, as well as cases associated with Down`s syndrome and familial syringoma. The eruptive occurrence of multiple syringomas in healthy persons has been reported rarely. We report a small case series of patients with syringomas, highlighting the different clinicopathologic manifestations and variations, and review the recent literature.
Acknowledgements
We thank Anne Kerber for excellent histological and immunohistological stainings.
Figures and Tables
Figure 1 Reactive syringomatous proliferation in conjunction with scarring alopecia due to lichen planopilaris (patient #1), H&E, ×200
![Figure 1 Reactive syringomatous proliferation in conjunction with scarring alopecia due to lichen planopilaris (patient #1), H&E, ×200](/cms/asset/ede4bec5-2203-4dca-8fc7-3631d5f4a34d/kder_a_10910641_f0001.gif)
Figure 3 Representative lesion of an eruptively disseminating syringomatosis (patient #3), H&E, ×100.
![Figure 3 Representative lesion of an eruptively disseminating syringomatosis (patient #3), H&E, ×100.](/cms/asset/1492629d-a050-4eca-8bb1-be4d9ef6559b/kder_a_10910641_f0003.gif)
Figure 6 Epithelial cords lined by one or two layers of polygonal epithelial cells with comma-like tails, stained with cytokeratin marker AE1/AE3, ×100.
![Figure 6 Epithelial cords lined by one or two layers of polygonal epithelial cells with comma-like tails, stained with cytokeratin marker AE1/AE3, ×100.](/cms/asset/b1b3d724-9247-4d20-97c9-265f60990cb7/kder_a_10910641_f0006.gif)
Table 1 Clinical data