Acute onset disseminated superficial porokeratosis associated with exacerbation of diabetes mellitus due to development of anti-insulin antibodies

Abstract

The development of disseminated superficial porokeratosis is occasionally observed in association with renal transplant, autoimmune diseases, and various hematological disorders, suggesting a certain immunosuppression may trigger a wide-spread abnormal keratinization. Here we report a case of sudden onset disseminated superficial porokeratosis associated with an exacerbation of diabetes mellitus due to an anti-insulin antibody formation. To our knowledge, this is the first report of disseminated superficial porokeratosis in a patient with severe diabetes mellitus.

Figures and Tables

Figure 1 Multiple annular hyperpigmented plaques with raised borders disseminated on right upper limbs.

Figure 2 Column of parakeratotic cells contained in invagination of epidermis and thinning of the granular layer, cornoid lamellae (Hematoxylin-eosin stain).