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Abstract
Skin is a model of choice in studies on aging. Indeed, skin aging can be modulated by internal and external factors, reflecting its complexity. Two types of skin aging have been identified: intrinsic, mainly genetically determined and extrinsic—also called "photo-aging"—resulting on the impact of environmental stress and more precisely of UV rays. Simplified in vitro models, based on cellular senescence, have been developed to study the relationship between UV and aging. These models vary on the cell type (fibroblasts or keratinocytes, normal or immortalized) and the type of UV used (UVA or UVB).
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Disclosure of Potential Conflicts of Interest
No potential conflicts of interest were disclosed.
Acknowledgments
F.D-C. and O.T. and are respectively Research Associate and Senior Research Associate of the FNRS, Belgium. We acknowledge the 'Direction Générale Opérationnelle de l'Economie, de l'Emploi et de la Recherche' (DGO6) of the Public Service of Wallonia (SPW) for the ‘Senegene’ Reseaux 2-project, no. 05/1/6192. We thank the European Commission for large scale Collaborative Project ‘MYOAGE’, contract HEALTH-F2-2009-223576 from the Seventh FP, for large scale Collaborative Project ‘MARKAGE’, contract HEALTH-2007–2.2.2.-3 from the Seventh FP and for Infrastructure 'QNano' Contract INFRASTRUCTURE-2010-1-262163.