Lack of genomic imprinting of DNA primase, polypeptide 2 (PRIM2) in human term placenta and white blood cells

Jaewook Chung Center for Comparative Medicine and Translational Research; North Carolina State University; Raleigh, NC USA

Shengdar Tsai Center for Comparative Medicine and Translational Research; North Carolina State University; Raleigh, NC USA

Andra H. James Department of Obstetrics and Gynecology; Duke University School of Medicine; Durham, NC USA

Betty H. Thames Department of Obstetrics and Gynecology; Duke University School of Medicine; Durham, NC USA

Stephanie Shytle Department of Obstetrics and Gynecology; Duke University School of Medicine; Durham, NC USA

Jorge A. Piedrahita Center for Comparative Medicine and Translational Research; North Carolina State University; Raleigh, NC USACorrespondence[email protected]

Abstract

PRIM2, encoding a subunit of primase involved in DNA replication and transcription, is expressed in the placenta and is crucial for mammalian development and growth. Its role in placental function is not well understood. Recently, PRIM2 was reported as imprinted in human white blood cells (WBC). We report here our failure to confirm imprinting of the PRIM2 locus in human placenta or WBC. The discordance between our results and those of others are likely due to an incorrectly annotated PRIM2 pseudogene found in the human genome database.

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Lack of genomic imprinting of DNA primase, polypeptide 2 (PRIM2) in human term placenta and white blood cells

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Lack of genomic imprinting of DNA primase, polypeptide 2 (PRIM2) in human term placenta and white blood cells

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