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Review

DNA methylation in endometrial cancer

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Pages 491-498 | Received 02 Mar 2010, Accepted 21 May 2010, Published online: 16 Aug 2010
 

Abstract

Endometrial cancer is the most commonly diagnosed gynecological cancer, and it has been shown to be a complex disease driven by abnormal genetic, and epigenetic alterations, as well as environmental factors. Epigenetic changes resulting in aberrant gene expression are dynamic and modifiable features of many cancer types. A significant epigenetic change is aberrant DNA methylation. In this review, we review evidence on the role of aberrant DNA methylation, examining changes in relation to endometrial carcinogenesis, and report on recent advances in the understanding of the contribution of aberrant DNA methylation to endometrial cancer with the emphasis on the role of dietary/ lifestyle and environmental factors, as well as opportunities and challenges of DNA methylation in endometrial cancer management and prevention.

Acknowledgement

This work was supported by the National Cancer Institute (R01CA 092040).

Figures and Tables

Table 1 Selected genes frequently silenced by DNA promoter methylation in endometrial carcinoma

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