Antibody persistence after Pandemic H1N1 2009 influenza vaccination among healthcare workers in Pune, India

Abstract

The healthcare workers having seroprotection at 3 weeks (n = 127) following Pandemic H1N1 2009 influenza vaccination were followed up for antibody persistence. Seroprotection at 12 mo (60.2%) was significantly lower as compared with 3 weeks (74.7%), 3 mo (77.8%) and 6 mo (75.4%). The vaccine provided seroprotection up to one year.

Keywords: :

• antibody persistence
• healthcare workers
• immune response
• influenza vaccination
• Pandemic H1N1 2009
• post-licensure

Disclosure of Potential Conflicts of Interest

No potential conflicts of interest were disclosed.

Acknowledgments

We acknowledge the Pune District Health Authorities for the help and support during field activities. We are also thankful to Mr. P.A. More and Miss S. Pagar for their technical contributions in field activities and data management respectively.

Funding

The Indian Council of Medical Research provided the funding.

Contributors

B.V.T. planned and executed the study, managed and analyzed data, wrote the manuscript and approved the final submission as corresponding author. S.D.P. managed specimen-testing protocols, analyzed and interpreted data, revised and approved the manuscript. Y.K.G. contributed in planning, execution and data management and reviewed and approved the final version of the manuscript. S.S.P. managed the assay protocols and performed assays. A.C.M. provided administrative support, provided inputs for study design, reviewed and approved the manuscript for submission.