Importance of neutralization sieve analyses when seeking correlates of HIV-1 vaccine efficacy

Abstract

This commentary describes a rationale for the use of breakthrough viruses from clinical trial participants to assess neutralizing antibodies as a correlate of HIV-1 vaccine efficacy. The rationale is based on principles of a genetic sieve analysis, where the 2 analyses may be cooperative for delineating neutralizing antibodies as a mechanistic correlate of protection.

Keywords: :

• neutralizing antibodies
• HIV
• vaccines
• correlates
• sieve

10.4161/hv.28950

Disclosure of Potential Conflicts of Interest

No potential conflicts of interest were disclosed.

Acknowledgements

The author thanks Celia LaBranche and Peter Gilbert for helpful comments during the writing of this manuscript. The author’s laboratory is funded by grants from US National Institutes of Health and the Bill and Melinda Gates Foundation.