The relevance of dengue virus genotypes surveillance at country level before vaccine approval

Abstract

Dengue is a major threat for public health in tropical and subtropical countries around the world. In the absence of a licensed vaccine and effective antiviral therapies, control measures have been based on education activities and vector elimination. Current efforts for developing a vaccine are both promising and troubling. At the advent of the introduction of a tetravalent dengue vaccine, molecular surveillance of the circulating genotypes in different geographical regions has gained considerable importance. A growing body of in vitro, preclinical, and clinical phase studies suggest that vaccine conferred protection in a geographical area could depends on the coincidence of the dengue virus genotypes included in the vaccine and those circulating. In this review we present the state-of-the-art in this field, highlighting the need of deeper knowledge on neutralizing immune response for making decisions about future vaccine approval and the potential need for different vaccine composition for regional administration.

Keywords:

• dengue virus
• vaccines
• neutralizing antibodies
• genotypes
• surveillance

Abbreviations:

• DENV, dengue viruses
• DC-SIGN, Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin
• Hsp70, heat shock protein 70
• Hsp90, heat shock protein 90
• ssRNA+, single-stranded positive-sense RNA viruses
• MRCA, more recent common ancestor
• UTR, untranslated region
• E, envelope protein
• M, membrane protein
• NS1, non-structural protein 1
• ADE, antibody-dependent enhancement