Abstract
Objectives: This paper identifies differences in the uptake rate of Gardasil and contrasts Gardasil uptake rate with the history of Hepatitis B vaccination. Methods: A targeted review of peer-reviewed journals and industry commentary was conducted. New trends were calculated and figures created based on secondary data. Results: The distribution of HPV vaccine does not conform to the geographic incidence rate of cervical cancer. Contrary to contemporary belief, school immunization mandates for Hepatitis B vaccines were not the impetus for their acceptance. Familial beliefs about HPV vaccines appear to be the most significant challenge to Gardasil uptake rate. Conclusions: Gardasil is at a critical juncture for increased uptake. Evidence-based educational interventions are needed.