Transcriptional repression by the Msx1 homeoprotein is associated with global redistribution of the H3K27me3 repressive mark to the nuclear periphery

Abstract

The spatial and temporal regulation of gene expression during development requires the concerted actions of sequence-specific transcriptional regulators and epigenetic chromatin modifiers, which are thought to function within precise nuclear compartments. However, coordination of these activities within the dynamic context of the nuclear environment is still largely unresolved. Here we discuss the implications of our recent work showing that transcriptional repression by the Msx1 homeoprotein is associated with global redistribution of the H3K27me3 repressive mark to the nuclear periphery during development.

Keywords: :

• EZH2
• H3K27me3
• Msx1
• PRC2
• differentiation
• epigenetic chromatin modifiers
• homeoprotein
• nuclear periphery
• transcriptional repression

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Acknowledgments

We thank Drs Shazia Irshad and Aditya Dutta for many discussions and helpful comments on the manuscript. This work was supported by the T.J. Martell Foundation for Leukemia, Cancer and AIDS Research (C.A.-S.) and by grant HD029446 (C.A.-S.).