The transport of integral membrane proteins across the nuclear pore complex

Abstract

The nuclear envelope protects and organizes the genome. The nuclear pore complexes embedded in the nuclear envelope allow selective transport of macromolecules between the cytosol and nucleoplasm, and as such help to control the flow of information from DNA to RNA to proteins. A growing list of integral membrane proteins of the nuclear envelope are described to function in the organization of the genome, as well as the assembly of the NPCs. Here, we discuss how the nuclear pore complex may sort these proteins to obtain a specific protein composition of the inner membrane.

Keywords: :

• inner nuclear membrane
• intrinsically disordered
• membrane protein
• nuclear envelope
• nuclear pore complex

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Acknowledgments

We would like to thank P. Lusk, J.K. Laba, R.A. Hapsari, A. Kralt, P. Popken, G.E. Janssens and U. Kutay for discussions and insightful comments. This work was supported by funding from the Netherlands Organization for Scientific Research (VIDI fellowship to L.M.V.; Top-subsidy grant 700.56.302 to B.P.)