Stochastic genome-nuclear lamina interactions

Abstract

The nuclear lamina (NL) is thought to aid in the spatial organization of interphase chromosomes by providing an anchoring platform for hundreds of large genomic regions named lamina associated domains (LADs). Recently, a new live-cell imaging approach demonstrated directly that LAD-NL interactions are dynamic and in part stochastic. Here we discuss implications of these new findings and introduce Lamin A and BAF as potential modulators of stochastic LAD positioning.

Keywords: :

• Lamin B1
• nuclear organization
• LADs
• single cell
• Lamin A
• chromatin domains
• BAF

This article refers to:

10.4161/nucl.28825

Disclosure of Potential Conflicts of Interest

No potential conflict of interest was disclosed.

Acknowledgments

We thank the NKI Genomics Core Facility for microarray hybridizations, and members of our laboratory for helpful suggestions. This work was supported by an EMBO Long-term Fellowship and NWO-ALW VENI (J.K.), and by NWO-ALW VICI (B.v.S.).