A Janus-faced role of the unfolded protein response in antitumor immunity

Navin R. Mahadevan The Laboratory of Immunology; Department of Medicine and Moores Cancer Center; University of California; San Diego, CA USA

Jeffrey J. Rodvold The Laboratory of Immunology; Department of Medicine and Moores Cancer Center; University of California; San Diego, CA USA

Maurizio Zanetti The Laboratory of Immunology; Department of Medicine and Moores Cancer Center; University of California; San Diego, CA USACorrespondence[email protected]

Abstract

The unfolded protein response (UPR) has been established as a cell-intrinsic mechanism of survival for malignant cells facing microenvironmental stressors. Recent evidence indicates that the UPR also modulates antitumor immunity. Here, we discuss the bi-faced role of the UPR as it both promotes and antagonizes antitumor T-cell immunity.

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No potential conflicts of interest were disclosed.

A Janus-faced role of the unfolded protein response in antitumor immunity

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A Janus-faced role of the unfolded protein response in antitumor immunity

Abstract

Disclosure of Potential Conflicts of Interest

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