Multifunctional γδ T cells and their receptors for targeted anticancer immunotherapy

Abstract

Human γδ T cells possess broad antitumor reactivity and are involved in the control of viral infections. We have recently described multifunctional γδ T cells induced by cytomegalovirus after allogenic stem cell transplantation, placing γδ T cells and their receptors in the spotlight for the development of novel anticancer immunotherapies.

Keywords: :

• T-cell receptor
• adoptive immunotherapy
• allogeneic stem cell transplantation
• cytomegalovirus
• leukemia
• γδ T cells

Disclosure of Potential Conflicts of Interest

Clinical trials were supported by Miltenyi Biotec. This work was supported by grants of the ZonMW 43400003, VIDI-ZonMW 917.11.337, LSBR 0902, AICR 10-736, KWF UU-2010-4669.