Prognostic value of the immune microenvironment in lung adenocarcinoma

Kyuichi Kadota Division of Thoracic Service; Department of Surgery; Memorial Sloan-Kettering Cancer Center; New York, NY USA; Department of Diagnostic Pathology; Faculty of Medicine; Kagawa University; Kagawa, Japan

Jun-ichi Nitadori Division of Thoracic Service; Department of Surgery; Memorial Sloan-Kettering Cancer Center; New York, NY USA

Prasad S. Adusumilli Division of Thoracic Service; Department of Surgery; Memorial Sloan-Kettering Cancer Center; New York, NY USA; Center for Cell Engineering; Memorial Sloan-Kettering Cancer Center; New York, NY USACorrespondence[email protected]

Abstract

We analyzed the immune microenvironment in the neoplastic and stromal components of Stage I lung adenocarcinoma lesions, finding that a high ratio of tumor-infiltrating FOXP3⁺ regulatory T cells to CD3⁺ lymphocytes, an elevated expression of the interleukin-7 receptor, as well as a reduced expression of the interleukin-12 receptor β2 all constitute independent factors of poor prognosis.

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No potential conflicts of interest were disclosed.

Prognostic value of the immune microenvironment in lung adenocarcinoma

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Prognostic value of the immune microenvironment in lung adenocarcinoma

Abstract

Disclosure of Potential Conflicts of Interest

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