EGFR expression levels affect the mode of action of EGFR-targeting monoclonal antibodies

Abstract

Epidermal growth factor receptor (EGFR) expression levels appear to modulate the efficacy of EGFR-targeting monoclonal antibodies. More specifically, we observed that high EGFR densities negatively affect the effects of EGFR-specific antibodies on EGFR phosphorylation yet exacerbate Fc-mediated tumor-cell killing. These results suggest that the predominant mode of action of EGFR-targeting antibodies depend on EGFR expression levels.

Keywords: :

• antibody
• epidermal growth factor receptor
• expression levels

Disclosure of Potential Conflicts of Interest

No potential conflicts of interest were disclosed.