Myeloid-derived suppressor cells as a novel target for the control of osteolytic bone disease

Abstract

Myeloid-derived suppressor cells (MDSC) from mice bearing bone metastases differentiate into functional osteoclasts in vitro and in vivo, through a signaling pathway that relies on nitric oxide. In addition, MDSC-targeting drugs have been shown to robustly inhibit osteolysis. Thus, MDSC stand out as novel osteoclast progenitors and hence as candidate targets for the control of osteolytic bone disease.

Keywords: :

• bone metastasis
• breast cancer
• myeloid-derived suppressor cells
• osteoclasts

Disclosure of Potential Conflicts of Interest

No potential conflicts of interest were disclosed.