Breaking tumor-induced immunosuppression with 5′-triphosphate siRNA silencing TGFβ and activating RIG-I

Abstract

Retinoic acid-inducible gene I (RIG-I) is a pattern recognition receptor that is activated by 5′-triphosphate RNA molecules to induce type I interferon secretion and apoptosis in response to viral infection. We have designed a bifunctional small-interfering RNA that combines transforming growth factor β silencing with RIG-I activation to break tumor-induced immunosuppression. This strategy showed therapeutic efficacy in a murine model of pancreatic cancer.

Keywords: :

• RIG-I
• TGFβ
• immunosuppression
• pancreatic cancer
• siRNA

Disclosure of Potential Conflicts of Interest

No potential conflicts of interest were disclosed.